In molecular biology, a cap analog is a synthetic molecule that mimics the structure of the natural cap found on messenger RNA (mRNA). This natural cap, typically m7G (7-methylguanosine), plays a crucial role in several cellular processes, particularly initiating mRNA translation.

 

Function: Replicate the natural cap's function during in vitro (outside a living cell) experiments, specifically mRNA synthesis.


Benefits:
• Enhance the efficiency of translation in cell-free systems.
• Increase the stability of mRNA molecules.
• Allow for incorporation of unique features not present in natural caps (e.g., fluorescent tags for tracking).

 

Applications: Primarily used in in vitro transcription reactions to generate capped RNA for various purposes:
• Studying protein translation.
• Microinjection experiments to introduce mRNA into cells.

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ON-089.svg

GpppG, 100mM Lithium Salt Solution

目录号: ON-089
分子式: C20H27N10O18P3 (free acid)
ON-085.svg

GpppG, lithium Salt

目录号: ON-085
分子式: C20H27N10O18P3 (free acid)
ON-136.svg

M7-GpppG

目录号: ON-136
分子式: C21H29N10O18P3
ON-137.svg

GpppA

目录号: ON-137
分子式: C20H27N10O17P3
ON-138.svg

M7-GpppA

目录号: ON-138
分子式: C21H29N10O17P3
ON-292.svg

M7G(3'-OMe-5')pppA(2'-OMe)•Na salt

目录号: ON-292
分子式: C23H33N10O17P3 (free acid)
ON-121.svg

ARCA, 100mM Sodium Salt Solution

目录号: ON-121
分子式: C22H32N10O18P3 (free acid)
ON-134

m7G(5')ppp(5')(2'-OMeA)pG·NH4

备注: GAG
目录号: ON-134
分子式: C32H43N15O24P4 (free acid)
ON-205

(3'-OMe-m7G)(5')ppp(5')(2'-OMeA)pG·NH4

备注: GAG
目录号: ON-205
分子式: C33H45N15O24P4 (free acid)